Bharti, Englund, M.C., Sjöblom, C., Dahl, U.,Bharti, Englund, M.C., Sjöblom, C., Dahl, U.,

Bharti, K., Liu, W., Csermely, T.,
Bertuzzi, S., Arnheiter, H., 2008. Alternative promoter use in eye development:
the complex role and regulation of the transcription factor MITF. Development
135, 1169–1178.

Carr, A.J., Vugler, A., Lawrence, J.,
Chen, L.L., Ahmado, A., Chen, F.K., Semo, M., Gias, C., da, Cruz, L., Moore,
H.D., Walsh, J., Coffey, P.J., 2009. Molecular characterization and functional
analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a
novel human retinal assay. Mol. Vis. 15, 283–295.

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Chopdar, A., Chakravarthy, U., Verma,
D., 2003. Age-related macular degeneration. Br. Med. J. 326, 485–488.

Chow, R.L., Lang, R.A., 2001. Early
eye development in vertebrates. Annu. Rev. Cell Dev. Biol. 17, 255–296.

Da, Cruz, L., Chen, F.K., Ahmado, A.,
Greenwood, J., Coffey, P., 2007. RPE transplantation and its role in retinal
disease. Prog. Retin. Eye Res. 26, 598–635.

Drukker, M., Katchman, H., Katz, G.,
Even-Tov, Friedman, S., Shezen, E., Hornstein, E., Mandelboim, O., Reisner, Y.,
Benvenisty, N., 2006. Human embryonic stem cells and their differentiated
derivatives are less susceptible to immune rejection than adult cells. Stem
Cells 24, 221–229.

Gouras, P., Flood, M.T., Kjedbye, H.,
Bilek, M.K., Eggers, H., 1985. Transplantation of cultured human retinal
epithelium to Bruch’s membrane of the owl monkey’s eye. Curr. Eye Res. 4,

Heins, N., Englund, M.C., Sjöblom,
C., Dahl, U., Tonning, A., Bergh, C., Lindahl, A., Hanson, C., Semb, H., 2004.
Derivation, characterization, and differentiation of human embryonic stem
cells. Stem Cells 22, 367–376.

Hirami, Y., Osakada, F., Takahashi,
K., Okita, K., Yamanaka, S., Ikeda, H., Yoshimura, N., Takahashi, M., 2009.
Generation of retinal cells from mouse and human induced pluripotent stem
cells. Neurosci. Lett. 458, 126–131.

Horsford, D.J., Nguyen, M.T., Sellar,
G.C., Kothary, R., Arnheiter, H., McInnes, R.R., 2005. Chx10 repression of Mitf
is required for the maintenance of mammalian neuroretinal identity. Development
132, 177–187.

Idelson, M., Alper, R., Obolensky,
A., Ben-Shushan, E., Hemo, I., Yachimovich-Cohen, N., Khaner, H., Smith, Y.,
Wiser, O., Gropp, M., Cohen, M.A., Even-Ram, S., Berman-Zaken, Y., Matzrafi,
L., Rechavi, G., Banin, E., Reubinoff, B., 2009. Directed differentiation of
human embryonic stem cells into functional retinal pigment epithelium cells.
Cell Stem Cell 5, 396–408.

Kawasaki, H., Suemori, H., Mizuseki,
K., Watanabe, K., Urano, F., Ichinose, H., Haruta, M., Takahashi, M.,
Yoshikawa, K., Nishikawa, S., Nakatsuji, N., Sasai, Y., 2002. Generation of
dopaminergic neurons and pigmented epithelia from primate ES cells by stromal
cell-derived inducing activity. Proc. Natl. Acad. Sci. U. S. A. 99, 1580–1585.

Kimbrel, E.A., Lanza, R., 2015.
Current status of pluripotent stem cells: moving the first therapies to the
clinic. Nat. Rev. Drug Discov. 14, 681–692.

King, N.J., Thomas, S.R., 2007.
Molecules in focus: indoleamine 2,3-dioxygenase. Int. J. Biochem. Cell Biol.
39, 2167–2172.

Klimanskaya, I., Hipp, J., Rezai,
K.A., West, M., Atala, A., Lanza, R., 2004. Derivation and comparative
assessment of retinal pigment epithelium from human embryonic stem cells using
transcriptomics. Cloning Stem Cells 6, 217–245.

Little, C.W., Castillo, B., DiLoreto,
D.A., Cox, C., Wyatt, J., del, Cerro, C., del, Cerro, M., 1996. Transplantation
of human fetal retinal pigment epithelium rescues photoreceptor cells from
degeneration in the Royal College of Surgeons rat retina. Invest. Ophthalmol.
Vis. Sci. 37, 204–211.

Mandal, A., Tipnis, S., Pal, R.,
Ravindran, G., Bose, B., Patki, A., Rao, M.S., Khanna, A., 2006.
Characterization and in vitro differentiation potential of a new human
embryonic stem cell line, ReliCellhES1. Differentiation 74, 81–90.

Mehta, A., Mathew, S., Viswanathan,
C., Sen, Majumdar, A., 2010. Intrinsic properties and external factors
determine the differentiation bias of human embryonic stem cell lines. Cell
Biol. Int. 34, 1021–1031.

Meisel, R., Zibert, A., Laryea, M.,
Göbel, U., Däubener, W., Dilloo, D., 2004. Human bone marrow stromal cells inhibit
allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan
degradation. Blood 103, 4619–4621.

Meyer, J.S., Shearer, R.L., Capowski,
E.E., Wright, L.S., Wallace, K.A., McMillan, E.L., Zhang, S.C., Gamm, D.M.,
2009. Modeling early retinal development with human embryonic and induced
pluripotent stem cells. Proc. Natl. Acad. Sci. U. S. A. 106, 16698–16703.

Oh, S.K., Kim, H.S., Ahn, H.J., Seol,
H.W., Kim, Y.Y., Park, Y.B., Yoon, C.J., Kim, D.W., Kim, S.H., Moon, S.Y.,
2005. Derivation and characterization of new human embryonic stem cell lines:
SNUhES1, SNUhES2, and SNUhES3. Stem Cells 23, 211–219.

Opas, M., 1994. Substratum mechanics
and cell differentiation. Int. Rev. Cytol. 150, 119–137.

Osakada, F., Ikeda, H., Mandai, M.,
Wataya, T., Watanabe, K., Yoshimura, N., Akaike, A., Sasai, Y., Takahashi, M.,
2008. Toward the generation of rod and cone photoreceptors from mouse, monkey
and human embryonic stem cells. Nat. Biotechnol. 26, 215–224.

Osakada, F., Ikeda, H., Sasai, Y.,
Takahashi, M., 2009a. Stepwise differentiation of pluripotent stem cells into
retinal cells. Nat. Protoc. 4, 811–824.

Osakada, F., Jin, Z.B., Hirami, Y.,
Ikeda, H., Danjyo, T., Watanabe, K., Sasai, Y., Takahashi, M., 2009b. In vitro
differentiation of retinal cells from human pluripotent stem cells by
small-molecule induction. J. Cell Sci. 122, 3169–3179.

Parysek, L.M., del, Cerro, M.,
Olmsted, J.B., 1985. Microtubule-associated protein 4 antibody: a new marker
for astroglia and oligodendroglia. Neuroscience 15, 869–875.

Radtke, N.D., Aramant, R.B., Petry,
H.M., Green, P.T., Pidwell, D.J., Seiler, M.J., 2008. Vision improvement in
retinal degeneration patients by implantation of retina together with retinal
pigment epithelium. Am. J. Ophthalmol. 146, 172–182.

Rattner, A., Nathans, J., 2006.
Macular degeneration: recent advances and therapeutic opportunities. Nat. Rev.
Neurosci. 7, 860–872.

Rowan, S., Chen, C.M., Young, T.L.,
Fisher, D.E., Cepko, C.L., 2004. Transdifferentiation of the retina into
pigmented cells in ocular retardation mice defines a new function of the
homeodomain gene Chx10. Development 131, 5139–5152.

Rowland, T.J., Buchholz, D.E., Clegg,
D.O., 2012. Pluripotent human stem cells for the treatment of retinal disease.
J. Cell Physiol. 227, 457–466.

Ryan, J.M., Barry, F., Murphy, J.M.,
Mahon, B.P., 2007. Interferon-gamma does not break, but promotes the
immunosuppressive capacity of adult human mesenchymal stem cells. Clin. Exp.
Immunol. 149, 353–363.

Sauvé, Y., Girman, S.V., Wang, S.,
Keegan, D.J., Lund, R.D., 2002. Preservation of visual responsiveness in the
superior colliculus of RCS rats after retinal pigment epithelium cell
transplantation. Neuroscience 114, 389–401.

Schwartz, S.D., Hubschman, J.P.,
Heilwell, G., Franco-Cardenas, V., Pan, C.K., Ostrick, R.M., Mickunas, E., Gay,
R., Klimanskaya, I., Lanza, R., 2012. Embryonic stem cell trials for macular
degeneration: a preliminary report. Lancet 379, 713–720.

Schwartz, S.D., Regillo, C.D., Lam,
B.L., Eliott, D., Rosenfeld, P.J., Gregori, N.Z., Hubschman, J.P., Davis, J.L.,
Heilwell, G., Spirn, M., Maguire, J., Gay, R., Bateman, J., Ostrick, R.M.,
Morris, D., Vincent, M., Anglade, E., Del, Priore, L.V., Lanza, R., 2015. Human
embryonic stem cell-derived retinal pigment epithelium in patients with
age-related macular degeneration and Stargardt’s macular dystrophy: follow-up
of two open-label phase 1/2 studies. Lancet 385, 509–516.

Shah, G., 1999. Why do we still use
serum in the production of biopharmaceuticals? Dev. Biol. Stand. 99, 17–22.

Simón, C., Escobedo, C., Valbuena,
D., Genbacev, O., Galan, A., Krtolica, A., Asensi, A., Sánchez, E., Esplugues,
J., Fisher, S., Pellicer, A., 2005. First derivation in Spain of human
embryonic stem cell lines: use of long-term cryopreserved embryos and
animal-free conditions. Fertil. Steril. 83, 246–249.

Svendsen, C.N., Fawcett, J.W.,
Bentlage, C., Dunnett, S.B., 1995. Increased survival of rat EGF-generated CNS
precursor cells using B27 supplemented medium. Exp. Brain Res. 102, 407–414.

Tasman, W., Rovner, B., 2004. Age-related
macular degeneration: Treating the whole patient. Arch. Ophthalmol. 122,

Tezel, T.H., Del, Priore, L.V., 1998.
Serum-free media for culturing and serial-passaging of adult human retinal
pigment epithelium. Exp. Eye Res. 66, 807–815.

Thomson, J.A., Itskovitz-Eldor, J.,
Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., Jones, J.M.,
1998. Embryonic stem cell lines derived from human blastocysts. Science 282,
1145–1147. Erratum in: Science 1998; 282:1827.

Tian, J., Ishibashi, K., Honda, S.,
Boylan, S.A., Hjelmeland, L.M., Handa, J.T., 2005. The expression of native and
cultured human retinal pigment epithelial cells grown in different culture
conditions. Br. J. Ophthalmol. 89, 1510–1517.

Tipnis, S., Viswanathan, C.,
Majumdar, A.S., 2010. Immunosuppressive properties of human umbilical
cord-derived mesenchymal stem cells: role of B7-H1 and IDO. Immunol. Cell Biol.
88, 795–806.

Usui, Y., Okunuki, Y., Hattori, T.,
Kezuka, T., Keino, H., Ebihara, N., Sugita, S., Usui, M., Goto, H., Takeuchi,
M., 2008. Functional expression of B7H1 on retinal pigment epithelial cells.
Exp. Eye Res. 86, 52–59.

Vaajasaari, H., Ilmarinen, T.,
Juuti-Uusitalo, K., Rajala, K., Onnela, N., Narkilahti, S., Suuronen, R.,
Hyttinen, J., Uusitalo, H., Skottman, H., 2011. Toward the defined and
xeno-free differentiation of functional human pluripotent stem cell-derived
retinal pigment epithelial cells. Mol. Vis. 17, 558–575.

Vasania, V.S., Prasad, P., Gill,
R.K., Mehta, A., Viswanathan, C., Sarang, S., Majumdar, A.S., 2011. Molecular
and cellular characterization of expanded and cryopreserved human limbal
epithelial stem cells reveal unique immunological properties. Exp. Eye Res. 92,

Vugler, A., Carr, A.J., Lawrence, J.,
Chen, L.L., Burrell, K., Wright, A., Lundh, P., Semo, M., Ahmado, A., Gias, C.,
da, Cruz, L., Moore, H., Andrews, P., Walsh, J., Coffey, P., 2008. Elucidating
the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and
retinal transplantation. Exp. Neurol. 214, 347–361.

Wachs, F.P., Couillard-Despres, S.,
Engelhardt, M., Wilhelm, D., Ploetz, S., Vroemen, M., Kaesbauer, J., Uyanik,
G., Klucken, J., Karl, C., Tebbing, J., Svendsen, C., Weidner, N., Kuhn, H.G.,
Winkler, J., Aigner, L., 2003. High efficacy of clonal growth and expansion of
adult neural stem cells. Lab. Invest. 83, 949–962.