Both the standard and patient-centered care groups presented with significantly lower depression scores over the 6 month, 12 month, and 18 month periods. There was no clinically significant difference between the groups improvement scores. Patients in the patient-centered group were less likely to change any treatments from baseline including medication treatment and counseling, while patients in the standard group increased their treatment rates. Patients in the patient-centered group were more likely to rate a clinician as participatory in their care. The patient-centered group also gave higher ratings for care provided by their case manager and were more likely to remain involved in their case management. The study was limited predominantly by details of the study design and setting. The study was only conducted in community clinics in the Delaware and Maryland region. Limitations include lack of variety in care settings and locations. In addition, the study only takes place over 18 months and is therefore limited by its length.A weakness is that the statistical tools are so complex that it is difficult to understand, obfuscating analysis of the methodology by the reader. Sentences like “…generalized linear mixed effects modeling (GLMMIX) approach, employing the logit link with the primary mean models and unstructured covariance matrix, was used to compare longitudinal binary outcomes such as participatory decision making and reports of treatment.” (Cooper et al., 2013) are so esoteric that they approach meaninglessness.Relevance of this study to clinical practiceThis study showed a small but statistically significant difference between the standard collaborative care and patient-centered, culturally tailored collaborative care groups. Both groups showed an improvement of symptoms, but the improvement was greater when the collaborative care measures were customized for African American patients. This result would encourage clinicians to choose collaborative care measures that are specific to their patient demographic needs.