drugs are used to lower cholesterol in the body, actually body needs some
cholesterol to work. If cholesterol level increases in blood it will stick to
the walls of arteries and narrows or even block arteries.
b diet and exercise does not reduce cholesterol levels did not
reduce, then it will be necessary to take medicine. Often, this medicine is a
statin. Statins lower LDL (bad) cholesterol levels and raise HDL (good)
cholesterol levels. This will decrease the formation of plaques in arteries.
are safe for most people. But these medicines are not recommended for pregnant
patients and patients with chronic liver disease. They can also cause serious
muscle problems. Some statins interact adversely with other drugs. This may result
in fewer side effects.
Statins – the good,
the bad and the controversy
Statins – the good
If cholesterol levels are high in the body it causes coronary
artery disease due to this fatty deposits builds up in the walls of arteries which
are supplying blood to the heart. Often these
deposits can harden and form plaques. Plaques are at risk of rupture, due to
this undersurface of the artery lining is exposed, provoking an injury
response. In this instance the blood flow through the artery can be blocked by
the clot formation. By this, starving of muscle occurs due to inadequate supply
of oxygen to heart muscles which may result in heart attack.Atherosclerosis process
described above is predominantly a silent process with no symptoms. Although
treatment for heart attacks has improved greatly over the years, a third of
heart attack patients still die within 28 days, with the majority of these
deaths occurring in the first 24 hours.
Statins has two main mechanisms of action. As per first
mechanism, they stabilise plaques by
making them less likely to rupture and therefore reducing the heart attacks. As
per Second, they reduce the levels of cholesterol in the blood by
inhibiting the enzyme in the liver that produces it. So less cholesterol level
in the blood stream means that there will be less deposition of plaques in
walls of the artery. There are two types of cholesterol: HDLwhich is a “good”, cholesterol
type; and LDL, the “bad “cholesterol type or disease-causing type. Cholesterol
is measured in units called mmol/L, and a large meta-analysis was conducted in 20121 and
concluded that for every 1 mmol/L drop in LDL (the “bad”) cholesterol, there
was a reduction of 24% in the risk of heart attack, 15% in the risk of stroke,
and 19% in the risk of death from coronary artery disease. The average
patient on an appropriate statin at the correct dose might
therefore expect their future cardiovascular risk to be halved.